San Francisco
| Sun, Sep 7 | @ SEA | W17–13 |
| Sun, Sep 14 | @ NO | W26–21 |
| Sun, Sep 21 | vs ARI | W16–15 |
| Sun, Sep 28 | vs JAX | L21–26 |
| Thu, Oct 2 | @ LAR | W26–23 |
| Sun, Oct 12 | @ TB | L19–30 |
| Sun, Oct 19 | vs ATL | W20–10 |
| Sun, Oct 26 | @ HOU | L15–26 |
| Sun, Nov 2 | @ NYG | W34–24 |
| Sun, Nov 9 | vsLAR | L26–42 |
| Sun, Nov 16 | @ARI | W41–22 |
| Mon, Nov 24 | vs CAR | W20–9 |
| Sun, Nov 30 | @ CLE | W26–8 |
| Sun, Dec 14 | vs TEN | W37–24 |
| Mon, Dec 22 | @ IND | W48–27 |
| Sun, Dec 28 | vs CHI | W42–38 |
| Sat, Jan 3 | vsSEA | L3–13 |
Alfred CollinsDT
out
Isaac GuerendoRB
out
Mykel WilliamsDE
out
Brandon AiyukWR
out
George KittleTE
out
Darrick ForrestS
Injured Reserve
Gracen HaltonDT
questionable
Andrew Farmer IIDE
questionable
Vederian LoweOT
questionable
Christian KirkWR
questionable
Nick BosaDE
questionable
Mac JonesQB
questionable
San Francisco 49ers injury designations via ESPN. Always confirm status before kickoff.
NFLnewsMyles Garrett dominated his first practice in horns, the new Chiefs-built secondary made plays immediately, and Matthew Stafford's light workload is by design. A very good first week at Loyola Marymount.
NFLnewsMike Evans caught deep balls, John Lynch closed the door on Brandon Aiyuk, and Kyle Shanahan worked through concussion protocol as 49ers camp opened in Santa Clara.
NFLnewsOn the eve of the first practice, Vita Vea asked out of Tampa Bay after stalled extension talks — headlining a week that also made life after Mike Evans official.
NFLnewsBaker Mayfield's self-imposed negotiating deadline lands the day veterans report, Vita Vea's extension talks are stuck, and a post-Evans, post-David roster opens camp July 28.
NFLnewsRookies reported July 18, Nick Bosa and Fred Warner are on track to return, and Mike Evans headlines a retooled roster as 49ers training camp gets rolling in Santa Clara.
NFLnewsSan Francisco's stars are back from injury and its receiving corps got a boost — don't overlook the 49ers in a loaded division.
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